The term biomolecular condensate refers to organelles without membrane and their subdomains. The presence of a membrane gives binding specialty to a biological structure. Discovering the binding method allows engineers to control biological systems and create them by 3d printing. However, biomolecular condensate does not have this feature makes it more difficult to program or print.
“Stickers” and “spacers” framework
“Stickers” and “spacers” framework - the term “stickers” refer to the multivalent site of biomolecular condensate, which allows the creation of stick, while the term “spacers” is the opposite of it. The majority of biomolecular condensate goes to phase separation during their formation process. Liquid-liquid phase separation (LLPS) is one of the types of phase separation, and the results of the wrong process of LLPS in cells contribute to neurological diseases and cancer. The tool “Stickers” and “spacers” framework allows controlling this process and makes it possible to prevent diseases.
The majority of biomolecular condensate can be divided into 2 large categories: cytoplasmic condensate and nuclear condensate. Since these two structures are core parts of any biological cell, the analysis of biomolecular condensate has a wide range of opportunities.